Instrument Calibration for Chemical Forensic and Environmental Analysis


Instructor: James Peterson
Product ID: 706289
Training Level: Intermediate

  • Duration: 60 Min
This webinar will present approaches to instrument calibration that are used by FBI, FDA and EPA in forensic and environmental analysis. It will emphasize the importance of calibration in obtaining accurate results in analysis of trace evidence, toxicological specimens and environmental samples.
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Why Should You Attend:

Do you struggle with knowing what to do with calibration curves that are not linear? Do you have trouble with analyses that produce anomalous or negative results? Are you not sure what methods to correct for inaccuracies are proper and acceptable? Did you know that the use of internal standards does not always correct for inaccuracies in a method? Find out how to approach these questions, when to apply the methods and why some approaches don’t work in this webinar.

Not all calibration curves are linear, that’s why they are called curves. Some curves require more calibration standards to define the curve. This webinar will provide a survey of methods to assess calibration curve linearity, ways to mathematically fit curves to the calibration data to obtain accurate results and present examples of improper use of calibration data. In addition, the you will learn how to assess the accuracy of an analysis and how to use the assessment to improve the analytical method. Methods of calibration using eternal standards, internal standards, extracted standards and standard additions will also be covered.

Areas Covered in the Webinar:

  • Types of calibration curves: Linear, exponential, quadratic, polynomial and weighted
  • Methods of calibration: External standard, internal standard, extracted standards, and standard additions
  • The number of standards required to define a calibration curve
  • How to assess the linearity of a calibration curve
  • How to apply mathematical curve fit routines to calibration curves and the routines that are not recommended in certain circumstances
  • The proper use of internal standards in a method and the critical steps and considerations in their application
  • How to assess accuracy of a method and how to use the assessment to improve the method
  • How to write an SOP that will accommodate the calibration methods that may be applied to the data obtained during calibration

Who Will Benefit:

  • Quality assurance manager
  • Method development and validation chemist
  • Forensic chemist
  • Toxicological chemist
  • Environmental chemist
  • Food chemist
  • Clinical chemist
  • Chemistry laboratory manager


  • Forensic laboratories
  • Environmental and water testing laboratories
  • Toxicological laboratories
  • Sports doping laboratories
  • Clinical laboratories
  • Food testing laboratories

Free Materials:

  • Reference documents
  • Agency guidance
  • SOP example
  • Articles
Instructor Profile:
James Peterson<

James Peterson
Forensic Chemistry Consultant, James C Peterson LLC

Dr. James C. Peterson has a Ph.D. in analytical chemistry from the University of Maryland and has over 36 years of analytical chemistry laboratory experience in academic, private, state, and federal laboratories. As a qualified chemist forensic examiner for the FBI Laboratory, he managed and oversaw forensic chemical examinations of evidence for the presence of chemical weapons. He has served as an analytical chemistry expert witness in legal cases related to the human exposure to toxic chemicals.

Dr. Peterson directed the start-up of five analytical laboratories which included the preparation of quality assurance documentation, instrumentation qualification and method development and validation. He has developed numerous methodologies for the detection and identification of toxic chemicals and drugs in human blood and urine, trace evidence and environmental samples and has given scientific presentations and training seminars at local, national and international conferences.

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