Residual Moisture Testing - Proven Techniques


Instructor: J. Jeff Schwegman
Product ID: 701952

  • Duration: 60 Min
This training will cover the various methods used to determine residual moisture in products ranging from bulk powders, to sterile freeze-dried products in vials, to foods.


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Why Should You Attend:

Monitoring and controlling residual moisture in powders, lyophilized solids, foods, etc can be a critical factor in achieving and maintaining quality products throughout their expected shelf life. Improper levels of moisture in products can result in poor powder flow properties, spoilage, polymorph changes, changes in compaction properties, microorganism growth promotion, higher degradation kinetics, and in the case of freeze-dried products, loss of physical structure and changes in reconstitution properties.

There are several methods typically employed to determine residual moisture, and the choice of method will be based on the sample tested, the level of residual moisture present, and the accuracy and precision required for testing. Additionally, many of these methods require a skill and knowledge in preparing and testing the samples if accurate results are to be achieved. In fact, in many cases, samples containing very low residual moisture, as in the case with freeze-dried products, accurate results for residual moisture are not achieved simply due to improper sample preparation and handling. Additionally, inaccurate and or imprecise results will be obtained if the correct method for testing residual moisture is not chosen.

In addition to covering the various techniques employed for residual moisture testing, this webinar will pay particular attention to choosing the correct technique for a specific application, specific details of sample preparation, sample handling, and data analysis, all of which can affect the final result.

Additionally, a high throughput, non-destructive technique will be discussed, which can be used, if applied correctly, for very rapid and accurate testing with 100% sample recovery.

Areas Covered in the Seminar:

  • Effects of residual moisture on dried products.
  • Gravimetric methods for residual moisture testing.
  • Near infrared spectroscopy method for residual moisture testing.
  • Volumetric Karl Fischer titration.
  • Coulometric Karl Fischer titration.
  • Specialized methods of residual moisture testing.
  • Proper handling techniques for external extraction in sealed vials.

Learning objectives:

  • Choosing the correct residual moisture test for your applications
  • Understanding the advantages and disadvantages of the different techniques covered
  • Understanding (via a step by step method) the proper technique for conducting a coulometric Karl Fischer external extraction (including equations)

Who Will Benefit:

This webinar will provide valuable assistance to those companies involved in the handling of powders, lyophilized products, solid pharmaceutical dosage forms, and dried foods.

  • Quality Control Scientists
  • Development Scientists
  • Production Management
  • Quality Assurance

Instructor Profile:

J. Jeff Schwegman , Ph.D. is currently the founder and chief executive officer of AB BioTechnologies where he develops formulations and lyophilization cycles. Additionally, Dr. Schwegman specializes in speaking and consulting in parenteral pre-formulation, formulation, analytical, and lyophilization of both small molecules and large biomolecules. He also holds patents and develops new technologies within the lyophilization field. Dr. Schwegman received his BS in Biochemistry from Indiana University in 1992 and began working at Cook Imaging in Bloomington Indiana, where he gained experience in analytical, formulation and process development. In 1999 he began graduate study in the Department of Industrial and Physical Pharmacy at Purdue University under the direction of Dr. Steve Nail, where his focus of research involved studying changes in the physical structure of biological molecules during lyophilization. Dr. Schwegman received his PhD from Purdue University in 2003, and returned to Bloomington where he worked at Baxter Pharmaceutical Solutions as a Research Scientist in the Pharmaceutical Development group. In November 2005, he left Baxter and formed BioConvergence LLC with 3 other founders which specialized in developing new formulations and manufacturing processes for parenteral products. In February 2008, he left BioConvergence, which has become a successful company, to form AB BioTechnologies. He is currently the course Director for a 3-day course called Lyophilization Technology which he teaches through the Center for Professional Advancement. He routinely lectures around the world on formulation, stabilization and process development of lyophilized products. He has also been an active member of AAPS since 2001.

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Our refund policy is governed by individual products and services refund policy mentioned against each of offerings. However in absence of specific refund policy of an offering below refund policy will be effective.
Registrants may cancel up to two working days prior to the course start date and will receive a letter of credit to be used towards a future course up to one year from date of issuance. ComplianceOnline would process/provide refund if the Live Webinar has been cancelled. The attendee could choose between the recorded version of the webinar or refund for any cancelled webinar. Refunds will not be given to participants who do not show up for the webinar. On-Demand Recordings can be requested in exchange. Webinar may be cancelled due to lack of enrolment or unavoidable factors. Registrants will be notified 24hours in advance if a cancellation occurs. Substitutions can happen any time. On-Demand Recording purchases will not be refunded as it is available for immediate streaming. However if you are not able to view the webinar or you have any concern about the content of the webinar please contact us at below email or by call mentioning your feedback for resolution of the matter. We respect feedback/opinions of our customers which enables us to improve our products and services. To contact us please email [email protected] call +1-888-717-2436 (Toll Free).




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